Joaquin Phoenix

Larry "Doc" Sportello

Josh Brolin

Lt. Det. Christian F. "Bigfoot" Bjornsen

Owen Wilson

Coy Harlingen

Katherine Waterston

Shasta Fay Hepworth

Reese Witherspoon

Deputy D.A. Penny Kimball

Benicio del Toro

Sauncho Smilax, Esq.

Jena Malone

Hope Harlingen

Joanna Newsom

Sortilège, who is also the narrator

Jordan Christian Hearn

Denis

Hong Chau

Jade

Jeannie Berlin

Aunt Reet

Maya Rudolph

Petunia Leeway

Michael Kenneth Williams

Tariq Khalil

Martin Short

Dr. Rudy Blatnoyd, D.D.S.

Sasha Pieterse

Japonica Fenway

Martin Donovan

Crocker Fenway

Eric Roberts

Michael Z. "Mickey" Wolfmann

Serena Scott Thomas

Sloane Wolfmann

Christopher Allen Nelson

Glenn Charlock

Sam Jaeger

Agent Flatweed

Timothy Simons

Agent Borderline

Jillian Bell

Chlorinda

Taylor Bonin

Ensenada Slim

Martin Dew

Dr. Buddy Tubeside